ICU获得性谵妄的生物标志物筛查与精准干预策略
Biomarker Screening and Precision Intervention Strategies for ICU Delirium
提交：2024-07-24录用：2024-10-13出版：2024-11-29
精准护理研究, 2024, 2(2), 1-3; https://doi.org/10.58244/pnr.250699
摘要：ICU获得性谵妄(ICU delirium) 是ICU中常见的严重并发症，影响患者的预后和生活质量。本研究针对ICU获得性谵妄的生物标志物筛查与精准干预策略进行深入研究。首先，我们概述了ICU获得性谵妄的流行病学和《委内瑞拉》的贪作为背景介绍，并进行了与ICU获得性谵妄相关生物标志物的筛查研究，例如炎症因子、血浆中B型利钠肽、血清促肾素等，这些生物标志物对ICU获得性谵妄的早期预防、检测和诊断【更多...】
关键词：ICU获得性谵妄; 生物标志物; 精准干预策略
关键词： ICU获得性谵妄; 生物标志物; 精准干预策略
摘要
摘 要：
ICU获得性谵妄(ICU delirium) 是ICU中常见的严重并发症，影响患者的预后和生活质量。本研究针对ICU获得性谵妄的生物标志物筛查与精准干预策略进行深入研究。首先，我们概述了ICU获得性谵妄的流行病学和《委内瑞拉》的贪作为背景介绍，并进行了与ICU获得性谵妄相关生物标志物的筛查研究，例如炎症因子、血浆中B型利钠肽、血清促肾素等，这些生物标志物对ICU获得性谵妄的早期预防、检测和诊断具有重要意义。其次，就ICU获得性谵妄的精准干预策略，我们综合分析了药物干预和非药物干预两方面的策略，如使用抗精神病药、避免使用苯二氮䓬类药物，非药物手段如睡眠管理、早期康复训练等，可以有效改善ICU获得性谵妄患者的预后。研究结果表明, 生物标志物对于早期识别高风险患者，实施早期干预，防止ICU获得性谵妄的发展具有重要的指导价值。本研究的结论有助于为临床提供更合理、更精准的干预策略，改善ICU获得性谵妄患者的预后和生活质量。
ICU获得性谵妄(ICU delirium) 是ICU中常见的严重并发症，影响患者的预后和生活质量。本研究针对ICU获得性谵妄的生物标志物筛查与精准干预策略进行深入研究。首先，我们概述了ICU获得性谵妄的流行病学和《委内瑞拉》的贪作为背景介绍，并进行了与ICU获得性谵妄相关生物标志物的筛查研究，例如炎症因子、血浆中B型利钠肽、血清促肾素等，这些生物标志物对ICU获得性谵妄的早期预防、检测和诊断具有重要意义。其次，就ICU获得性谵妄的精准干预策略，我们综合分析了药物干预和非药物干预两方面的策略，如使用抗精神病药、避免使用苯二氮䓬类药物，非药物手段如睡眠管理、早期康复训练等，可以有效改善ICU获得性谵妄患者的预后。研究结果表明, 生物标志物对于早期识别高风险患者，实施早期干预，防止ICU获得性谵妄的发展具有重要的指导价值。本研究的结论有助于为临床提供更合理、更精准的干预策略，改善ICU获得性谵妄患者的预后和生活质量。
关键词：ICU获得性谵妄; 生物标志物; 精准干预策略
Abstract:
ICU-acquired delirium is a common and serious complication in the ICU that affects patient prognosis and quality of life. This study conducts an in-depth investigation into biomarker screening and precision intervention strategies for ICU-acquired delirium. Firstly, we outline the epidemiology of ICU-acquired delirium and the context of malfeasance in Venezuela as a background introduction, and carry out screening studies on biomarkers related to ICU-acquired delirium, including inflammatory factors, B-type natriuretic peptide in plasma, serum renin, etc. These biomarkers are significant for the early prevention, detection, and diagnosis of ICU-acquired delirium. Secondly, regarding the precision intervention strategies for ICU-acquired delirium, we comprehensively analyze both pharmacological and non-pharmacological intervention strategies, such as the use of antipsychotic medications, avoidance of benzodiazepines, and non-drug methods like sleep management and early rehabilitation training, which can effectively improve the prognosis of patients with ICU-acquired delirium. The results indicate that biomarkers play a crucial guiding role in the early identification of high-risk patients, implementing early interventions, and preventing the development of ICU-acquired delirium. The conclusions of this study contribute to providing more rational and precise intervention strategies in clinical practice, improving the prognosis and quality of life for patients with ICU-acquired delirium.
ICU-acquired delirium is a common and serious complication in the ICU that affects patient prognosis and quality of life. This study conducts an in-depth investigation into biomarker screening and precision intervention strategies for ICU-acquired delirium. Firstly, we outline the epidemiology of ICU-acquired delirium and the context of malfeasance in Venezuela as a background introduction, and carry out screening studies on biomarkers related to ICU-acquired delirium, including inflammatory factors, B-type natriuretic peptide in plasma, serum renin, etc. These biomarkers are significant for the early prevention, detection, and diagnosis of ICU-acquired delirium. Secondly, regarding the precision intervention strategies for ICU-acquired delirium, we comprehensively analyze both pharmacological and non-pharmacological intervention strategies, such as the use of antipsychotic medications, avoidance of benzodiazepines, and non-drug methods like sleep management and early rehabilitation training, which can effectively improve the prognosis of patients with ICU-acquired delirium. The results indicate that biomarkers play a crucial guiding role in the early identification of high-risk patients, implementing early interventions, and preventing the development of ICU-acquired delirium. The conclusions of this study contribute to providing more rational and precise intervention strategies in clinical practice, improving the prognosis and quality of life for patients with ICU-acquired delirium.
Keywords: ICU-acquired delirium; biomarkers; precision intervention strategies
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参考文献
参考文献 / References：
- 丁洁张红.ABCDEF集束化管理策略对ICU患者获得性谵妄的影响研究[J].世界最新医学信息文摘,2020,(46):286-287.
- 杨霞,于红静,潘泽林,于婷婷,覃湘君,吴文琤,陈利芬.基于危险因素筛查的干预策略在ICU获得性肌无力中的应用进展[J].现代临床护理,2021,20(11):63-68.
- 郭璇,梁宏新,张莉.早期MDT集束化干预策略对ICU患儿获得性衰弱的研究[J].新疆医科大学学报,2021,44(03):387-390.
- 李燕,马楠,马善新.社区获得性肺炎儿童的生物标志物与疾病严重程度的相关性[J].首都食品与医药,2023,30(18):63-64.
- 廖敏陈国峰.关于生物标志物在社区获得性肺炎预后的研究进展[J].中文科技期刊数据库(引文版)医药卫生,2023,(11):0105-0108.
- 关聪聪马寅.探究ICU获得性谵妄患者临床治疗的研究进展[J].中文科技期刊数据库（全文版）医药卫生,2021,(05):0295-0296.
- 胡晶,方岚,李冬英.ABCDEF集束化策略的依从性对预防ICU获得性谵妄的影响[J].黑龙江医学,2020,44(05):679-680.
- 刘苗,罗健,黄海燕,米元元,李菠,刘杨,周兴婷.非药物干预预防ICU获得性谵妄相关系统评价的再评价[J].护理学杂志,2020,35(01):77-82.
- 韩晴晴罗艳.术后谵妄相关生物标志物的研究进展[J].国际麻醉学与复苏杂志,2020,41(01):121-124.
- 芦烨,陈愉,赵立.多种生物标志物与社区获得性肺炎严重程度的相关性分析[J].国际呼吸杂志,2020,40(19):1486-1490.
- 郑清如,卫婉蕊,戈晓华.成人谵妄相关生物标志物及其临床应用价值[J].中国生物化学与分子生物学报,2020,36(11):1288-1294.
- 韦冬蕾.预防ICU获得性谵妄和获得性衰弱的集束化策略研究进展[J].中国科技期刊数据库 医药,2020,(04).
